The Kisspeptin System in Male Reproduction
نویسندگان
چکیده
The kisspeptin system includes the cleavage products Kiss1 precursor and receptor (Kiss1R). It was originally discovered studied in cancer metastasis, but identification of KISS1/KISS1R gene mutations causing hypogonadotropic hypogonadism (HH) revealed unexpected effects reproduction. Nowadays, is main central gatekeeper reproductive axis at puberty adulthood, it also has a widespread functional role control endocrine functions. At periphery, Kiss1R are expressed testes, need for signaling spermatogenesis sperm quality still unclear debated. This brief manuscript summarizes findings on male reproduction; upcoming data maturation discussed.
منابع مشابه
GPR54 and kisspeptin in reproduction.
Kisspeptins, the peptide products of the KiSS-1 gene, were identified in 2001 as natural ligands of the previously orphan G protein-coupled receptor, GPR54. They include, among others, metastin and kisspeptin-10. The known biological functions of kisspeptins were initially restricted to their ability to suppress tumour metastasis, hence the name of metastin. However, in late 2003, two groups in...
متن کاملThe Role of Kisspeptin in Female Reproduction
Context Kisspeptin (KISS1), a recently discovered neuropeptide that acts upstream of gonadotropin-releasing hormone (GnRH) neurons, is critical for maturation and function of the reproductive axis. This review aimed at providing comprehensive and up-to-date information on Kisspeptin and its role in female reproduction. Evidence Acquisition A literature review was performed using PubMed for al...
متن کاملThe role of kisspeptin signaling in reproduction.
Kisspeptins are a group of peptides that stimulate GnRH release and are required for puberty and maintenance of normal reproductive function. This review focuses on our understanding of the way in which kisspeptin signaling regulates mammalian fertility and how they act as central integrators of different hormonal and physiological signals.
متن کاملKisspeptin/Kisspeptin Receptor System in the Ovary
Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating ovulation in sexually mature females via the central control of the hypothalamic-pituitary-gonadal axis. Recent studies have shown that kisspeptin and its receptor kisspeptin receptor (KISS1R) are expressed in the mammalian ovary. Convincing evidence indicates that kisspeptins can activate a wide v...
متن کاملKisspeptin and energy balance in reproduction.
Kisspeptin is vital for the neuroendocrine regulation of GNRH secretion. Kisspeptin neurons are now recognized as a central pathway responsible for conveying key homeostatic information to GNRH neurons. This pathway is likely to mediate the well-established link between energy balance and reproductive function. Thus, in states of severely altered energy balance (either negative or positive), fe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrines
سال: 2022
ISSN: ['2673-396X']
DOI: https://doi.org/10.3390/endocrines3020015